Award Number : DAMD 17 - 00 - 2 - 0018 TITLE : Mechanisms in Chronic Multisymptom Illnesses

Presentations – (Note: All 2006 abstracts were presented in last year’s annual report.) 2007 (pdfs of each are appended) Clauw DJ, Belfer I, Max M, Williams DA, Gracely RH, McLean SA, Harris RE, Neely A, Bair E, Diatchenko L, Maixner W. Increased Frequency of the Minor Allele for beta-3 Adrenergic Receptors in Individuals with Fibromyalgia and Related Syndromes. Accepted by the American College of Rheumatology 71 Annual Scientific Meeting, Boston, MA, Nov 7-11, 2007. Glass JM, Harris RC, Sundgren PC, Pang Y, Gracely RH, Clauw DJ. Variation in Glutamate and Glutamine Levels within the Inslula are associated with Improvements in Working Memory in Fibromyalgia (FM). Accepted by the American College of Rheumatology 71 Annual Scientific Meeting, Boston, MA, Nov 7-11, 2007. Glass JM, Lyden AK, Byrne-Dugan CJ, Groner KH, Ambrose KR, Grace PJ, Williams DA, Gracely RH, Clauw DJ. Effects of Sleep Restriction and Exercise Deprivation on Mood, Pain, Fatigue, Somatic Symptoms and Cognition in Healthy Adults. Accepted by the American College of Rheumatology 71 Annual Scientific Meeting, Boston, MA, Nov 7-11, 2007. Glass JM, Lyden AK, Byrne-Dugan CJ, Groner KH, Ambrose KR, Gracely RH, Williams DA, Clauw DJ. Baseline Heart Rate Variability Predicts Changes in Pain and Cognition, but not Mood or Fatigue after Exercise and Sleep Restriction. Accepted by the American College of Rheumatology 71 Annual Scientific Meeting, Boston, MA, Nov 7-11, 2007. Glass JM, Park DC, Crofford LJ, Fougnie D, Clauw DJ. Working Memory in Fibromyalgia Patients: Impaired Function Caused by Distracting Information, Not Rapid Decay of Stored Information. Accepted by the American College of Rheumatology 71 Annual Scientific Meeting, Boston, MA, Nov 7-11, 2007. Harris R, Scott D, Gracely R, Clauw D, Zubieta, J. Differential changes in mu-opioid receptor (MOR) availability following acupuncture and sham acupuncture therapy in fibromyalgia (FM). J Pain (abstract supplement), 8, 4, S24, 2007. Harris R, Scott D, Guevara M, Gracely R, Zubieta J, Clauw D. mu-Opioid receptor (MOR) binding predicts differential responsiveness to acupuncture and sham acupuncture therapy in fibromyalgia (FM). J Pain (abstract supplement), 8, 4, S49, 2007. Harris RH, Sundgren PC, Pang Y, Khatri N, Gracely RH, Clauw DJ. Variation in Glutamate and Glutamine Levels within the Insula are Associated with Improvements in Clinical and Experimental Pain in Fibromyalgia (FM). Accepted by the American College of Rheumatology 71 Annual Scientific Meeting, Boston, MA, Nov 7-11, 2007. Harris RE, Zubieta JK, Scott DJ, Mayo-Bond L, Gracely RH, Clauw DJ. Differential Sustained Changes in μ-Opioid Receptor (MOR) Availability Following Acupuncture and Sham